Mtdna haplogroups

Sale Ends April 26th. Follow the path of your female ancestors and connect with mtDNA relatives. Use mtDNA to determine where your direct maternal ancestors came from, their locations in historic times and how they migrated throughout the world.

Explore your direct maternal line and geographic origins. Uncover your maternal heritage going back to Africa. Trace your female ancestors' ancient migration paths. The mtFull Sequence video is a feature included with the mtFull Sequence test.

It tells the story of your maternal ancestry and is a fun way to share your results with friends and family. While men receive mitochondrial DNA from their mother, they do not pass it on to their children. Testing mtDNA allows for investigation into your maternal line and can help identify living relatives whose mtDNA is similar to yours, as well as ancient migration routes your maternal ancestors may have taken.

When humans left Africa tens of thousands of years ago, they departed in small groups that migrated into different parts of the world.

Over many generations, each group developed distinct mutations allowing us to identify one from the other.

We call these groups of mutations haplogroups, and they can tell us which migratory routes our maternal ancestors traveled. However, you can use mtDNA results with your personal genealogy research to contact your matches to find out more about where your common ancestors may be from.

This can mean that your lineage has survived and reproduced well. As a result, many people share the same signature. We recommend testing up to the Full Sequence level, if you have not already. If you have, we recommend the Family Finder test, and for you to encourage as many Full Sequence matches as possible to also do Family Finder.

Anyone who also matches you in that test will share a common ancestor within 5 generations. Records databases are also helpful for researching your connections with your matches. If you do not have mtDNA matches, or only a few matches, you may be the first person, or one of the first people with your mtDNA signature haplotype in our database.

This means that no one else from your lineage has tested. As the database grows, you will continue to be compared against new results, and you will be notified by email of any new matches. If you have questions about any of your results, you can either contact one of our Customer Support Representatives or look through our mtDNA pages in our Learning Center to learn all about mtDNA testing! Celebrate DNA Day. Explore your direct maternal line and geographic origins Uncover your maternal heritage going back to Africa Trace your female ancestors' ancient migration paths.

Sorry, your browser doesn't support embedded videos. With the world's largest mtDNA database, our advanced mtDNA tests can be used by both males and females to trace your direct and distant maternal lineage.But what exactly is a haplogroup, and why should you care?

For basic haplogroup information, I recommend 23andMe. At its simplest, a haplogroup is a group of people who share ancient origins. First, because we get our genes through our ancestors, that means nearly everyone who is part of a certain haplogroup is related, though it could be many, many generations back. In some cases, your haplogroup can help you connect with living relatives today, and even groups of genealogical researchers all tracing the same family lines.

In other cases, we can trace how a haplogroup migrated over time. A paternal line, stretching father to father to father back through time, is traced using YDNA testing. This tests part of the DNA that only men have, and it is passed down almost unchanged from one generation to the next. Men carry mtDNA, but do not pass it on to their children; only women do. So just how can you find out what your personal haplogroups are?

You have to take a DNA test. But not just any test will do. That can be great for finding living relatives and ethnicity, but tells you nothing about your ancient past. Be sure to check which test you are taking before you pay.

Because a woman does not carry YDNA, if she wants to determine her paternal haplogroup, she needs to have a male relative tested instead, like her brother, father, or paternal uncle. Scientists use letters and number to identify different haplogroups. The first letter indicates the major group, while other letters and numbers are used for more recent changes in the DNA.

E haplogroups are historically found in Africa. There are two major divisions of the E haplogroup, E1 and E2. For example, if you are part of the E1b1a1 haplogroup, your ancestor likely came from southern Africa. But if you are part of E1b1b1b1a, then your ancestors were likely Berbers, who lived in northwest Africa.

Maternal haplogroups use a similar system, which can get confusing. It is very important to note that the maternal and paternal groups are completely different, even if they have the same number. Be sure you know which type of DNA you are looking at.Today, much of what we know is raw material from Geno 2. This is built around the structure of the mtDNA Phylotree. The encyclopedia brings the data from those sources together in a format that allows new knowledge of our maternal origins to emerge.

mtdna haplogroups

A Haplogroup A is a branch on the maternal tree of human kind. It is a child of major haplogroup N. It was likely born in East Asia around 24, years ago. Behar et al. Through historic travels, members of this line live across East Asia and the Americas. A1 Haplogroup A1 is a branch on the maternal tree of humanity.

It was born between 7, and 18, years ago Behar et al. It is worth noting that prior to Phylotree build 16 this lineage was known as A4a.

A10 Haplogroup A10 is a branch on the maternal tree of human kind. Its age is between 3, and 12, years Behar et al. A11 Haplogroup A11 is an Asian branch on the maternal tree of human kind. The woman who founded this line lived between 12, and 21, years ago Behar et al b. This line was likely born in the Tibetan Plateau based on the origins for its daughter lines. A11a Haplogroup A11a is a branch on the maternal tree of human kind.

Its age is between 1, and 10, years Behar et al. A11b Haplogroup A11b is a branch on the maternal tree of human kind. Its age is between 4, and 15, years Behar et al. A12 Haplogroup A12 is a Siberian branch on the maternal tree of humanity. Its age has not been determined.

How to Find Your Haplogroup

A12a Haplogroup A12a is a branch on the maternal tree of humanity. It is difficult to be sure with limited data, but this branch likely originates in Siberia.

A13 Haplogroup A13 is an Asia branch on the maternal tree of humanity. Its age and precise origin are not yet clear. A14 Haplogroup A14 is a branch on the maternal tree of humanity. Its age has not been determined, and, because it is found in a wide range of modern populations, its exact origin in Asia is unclear.This third article focuses on haplogroups. They look so simple — a few letters and numbers — but haplogroups are a lot more sophisticated than they appear and are infinitely interesting!

A haplogroup is a designation that you can think of as your genetic clan reaching far back in time. The description of a haplogroup is the same for both Y and mitochondrial DNA, but the designations and processes of assigning haplogroups are different, so the balance of this article only refers to mitochondrial DNA haplogroups.

This map is interactive on your personal page, so you can view your or any other haplogroup highlighted on the map. On the frequency tab of the Migration Map, you can view the frequency of your haplogroup in any specific location.

The mitochondrial haplogroup J contains several sub-lineages. The original haplogroup J originated in the Near East approximately 50, years ago. Within Europe, sub-lineages of haplogroup J have distinct and interesting distributions. Haplogroup J1 is found distributed throughout Europe, from Britain to Iberia and along the Mediterranean coast. This widespread distribution strongly suggests that haplogroup J1 was part of the Neolithic spread of agriculture into Europe from the Near East beginning approximately 10, years ago.

Therefore, 1 is a major branch of haplogroup J, c is a smaller branch sprouting off of J1, 2 is a branch off of J1c, and f is the last leaf, at least for now. Haplogroups were named in the order they were discovered, using the alphabet, A-Z except O. Branches are indicated by subsequent numbers and letters. Build 17 of the phylogenetic tree includes branchesincreasing from in build Occasionally branches are sawed off and reconnected elsewhere, which sometimes plays havoc with the logical naming structure because they are renamed completely on the new branch.

This happened when haplogroup A4 was retired in Build 17 and is now repositioned on the tree as haplogroup A1. You can mouse over the little flag icons or click on the 3 dots to the right for a country report. J1c2f is the lowest leaf on this branch of the tree, for now, so there is no difference in the columns. However, if we look at the country report for haplogroup J1c2, the immediate upstream haplogroup above J1c2f, you can see the differences in the columns showing people who are members of haplogroup J1c2 and also downstream branches.

I wrote more about how to use the new public tree here. First, the official mitochondrial tree is the Phylotree, here. The Phylotree has been the defacto location for multiple entities to combine their information, uploading academic samples to GenBanka repository utilized by Phylotree for all researchers to use in the classification efforts.

You can read more about GenBank here. Prior to Phylotree, each interested entity was creating their own names and the result was chaotic confusion. The major criteria for haplogroup assignments are:. Periodically, the Phylotree is updated.

The current version is Build 17, which I wrote about here. For each vendor to update your haplogroup, they have to redo their classification algorithm behind the scenes, of course, then rerun their entire customer database against the new criteria.In human geneticsa human mitochondrial DNA haplogroup is a haplogroup defined by differences in human mitochondrial DNA.

Haplogroups are used to represent the major branch points on the mitochondrial phylogenetic tree. Understanding the evolutionary path of the female lineage has helped population geneticists trace the matrilineal inheritance of modern humans back to human origins in Africa and the subsequent spread around the globe. As haplogroups were named in the order of their discovery, the alphabetical ordering does not have any meaning in terms of actual genetic relationships.

The hypothetical woman at the root of all these groups meaning just the mitochondrial DNA haplogroups is the matrilineal most recent common ancestor MRCA for all currently living humans. She is commonly called Mitochondrial Eve. The rate at which mitochondrial DNA mutates is known as the mitochondrial molecular clock. It's an area of ongoing research with one study reporting one mutation per years. This phylogenetic tree is based Van Oven From Wikipedia, the free encyclopedia.

Haplogroup defined by differences in human mitochondrial DNA. Further information: Molecular phylogeny. Y-chromosome haplogroups by population. Further information: Human mitochondrial molecular clock. BMC Genomics. Investig Genet. Human Mutation. Archived from the original PDF on Molecular Biology and Evolution.

Categories : Human mtDNA haplogroups. Hidden categories: CS1 errors: missing periodical Articles with short description Commons category link is on Wikidata. Namespaces Article Talk.

Views Read Edit View history. In other projects Wikimedia Commons. By using this site, you agree to the Terms of Use and Privacy Policy. Part of a series on. East Africa or West Asia. Mitochondrial Eve L.There are also numerous projects for the various subclades within the major haplogroups.


Membership of subclade projects is usually restricted to those who have taken a test that sequences the full mitochondrial genome scientifically called the mtGenome. Other projects have external website facilities where they are able to display results from other testing companies. This will allow the project administrator to have access to your mutations list in case you have any questions.

The admin might also be able to provide a more detailed subclade assignment than that provided by Family Tree DNA, based on the up-to-date mtDNA tree published on Phylotree.

mtDNA Testing for Genetic Genealogy

Alternatively you can follow the instructions in this blog post entitled Your privacy and showing your mtDNA coding region mutations. Project admins are encouraged to convert the external links shown here to Wiki pages for their projects. Genographic Project participants can transfer their results to the FTDNA database in order to join the relevant haplogroup project. MtDNA haplogroup I and subclades project.

MtDNA haplogroup K project. MtDNA haplogroup M and subclades project. MtDNA haplogroup R and subclades project. MtDNA haplogroup U4 project. MtDNA haplogroup U8 project. List of mtDNA haplogroup projects Contents.As a haplogroup consists of similar haplotypes, it is usually possible to predict a haplogroup from haplotypes. Haplogroups pertain to a single line of descent. As such, membership of a haplogroup, by any individual, relies on a relatively small proportion of the genetic material possessed by that individual.

Each haplogroup originates from, and remains part of, a preceding single haplogroup or paragroup. As such, any related group of haplogroups may be precisely modelled as a nested hierarchyin which each set haplogroup is also a subset of a single broader set as opposed, that is, to biparental models, such as human family trees.

Y-DNA is passed solely along the patrilineal line, from father to son, while mtDNA is passed down the matrilineal line, from mother to offspring of both sexes. Neither recombinesand thus Y-DNA and mtDNA change only by chance mutation at each generation with no intermixture between parents' genetic material.

Mitochondria are small organelles that lie in the cytoplasm of eukaryotic cellssuch as those of humans. Their primary function is to provide energy to the cell. Mitochondria are thought to be reduced descendants of symbiotic bacteria that were once free living. One indication that mitochondria were once free living is that each contains a circular DNAcalled mitochondrial DNA mtDNAwhose structure is more similar to bacteria than eukaryotic organisms see endosymbiotic theory.

The overwhelming majority of a human's DNA is contained in the chromosomes in the nucleus of the cell, but mtDNA is an exception. An individual inherits his or her cytoplasm and the organelles contained by that cytoplasm exclusively from the maternal ovum egg cell ; sperm only pass on the chromosomal DNA, all paternal mitochondria are digested in the oocyte.

When a mutation arises in a mtDNA molecule, the mutation is therefore passed in a direct female line of descent. Mutations are copying mistakes in the DNA sequence. Single mistakes are called single nucleotide polymorphisms SNPs. Human Y chromosomes are male-specific sex chromosomes ; nearly all humans that possess a Y chromosome will be morphologically male.

Therefore, the Y chromosome and any mutations that arise in it are passed on from father to son in a direct male line of descent. This means the Y chromosome and mtDNA share specific properties.

mtdna haplogroups

Other chromosomes, autosomes and X chromosomes in women, share their genetic material called crossing over leading to recombination during meiosis a special type of cell division that occurs for the purposes of sexual reproduction.

Effectively this means that the genetic material from these chromosomes gets mixed up in every generation, and so any new mutations are passed down randomly from parents to offspring.

The special feature that both Y chromosomes and mtDNA display is that mutations can accrue along a certain segment of both molecules and these mutations remain fixed in place on the DNA.

Furthermore, the historical sequence of these mutations can also be inferred.

mtdna haplogroups

For example, if a set of ten Y chromosomes derived from ten different men contains a mutation, A, but only five of these chromosomes contain a second mutation, B, then it must be the case that mutation B occurred after mutation A. Furthermore, all ten men who carry the chromosome with mutation A are the direct male line descendants of the same man who was the first person to carry this mutation. The first man to carry mutation B was also a direct male line descendant of this man, but is also the direct male line ancestor of all men carrying mutation B.

Series of mutations such as this form molecular lineages. Furthermore, each mutation defines a set of specific Y chromosomes called a haplogroup. All men carrying mutation A form a single haplogroup, and all men carrying mutation B are part of this haplogroup, but mutation B also defines a more recent haplogroup which is a subgroup or subclade of its own to which men carrying only mutation A do not belong.

Both mtDNA and Y chromosomes are grouped into lineages and haplogroups; these are often presented as tree like diagrams. It is usually assumed that there is little natural selection for or against a particular haplotype mutation which has survived to the present day, [ citation needed ] so apart from mutation rates which may vary from one marker to another the main driver of population genetics affecting the proportions of haplotypes in a population is genetic drift —random fluctuation caused by the sampling randomness of which members of the population happen to pass their DNA on to members of the next generation of the appropriate sex.

In a large population with efficient mixing the rate of genetic drift for common alleles is very low; however, in a very small interbreeding population the proportions can change much more quickly. The marked geographical variations and concentrations of particular haplotypes and groups of haplotypes therefore witness the distinctive effects of repeated population bottlenecks or founder events followed by population separations and increases.

The lineages which can be traced back from the present will not reflect the full genetic variation of the older population: genetic drift means that some of the variants will have died out. The cost of full Y-DNA and mtDNA sequence tests has limited the availability of data; however, their cost has dropped dramatically in the last decade.